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3) dt The total concentration in the tissue can be written as the contribution from both vascular and interstitial compartments as Ct vb × Cb ve × Ce.

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Res. 2 McDonald Criteria for the Diagnosis of Clinically Definitea Multiple Sclerosis (CDMS) 2 Attacksb 2 lesions on examinationc 2 Attacks 1 lesion on examination [MRI (a)d or 2 MRI lesions abnormal CSF] 1 Attack 2 lesions on examination MRI (b)e 1 Attack 1 lesion on examination [MRI (a)d or 2 MRI lesions abnormal CSF] MRI (b)e Progressive disease abnormal CSF MRI (b)e a) [9 T2 MRI lesions or 2 spinal cord lesions or 48 brain MRI lesions 1 spinal cord lesion] OR b) Abnormal (Visually Evolved Potentials) VEPc [4 brain MRI lesions or 4 brain MRI lesions 1 spinal cord lesion] From Frohman et al.Macmillan, New York, 1979, chap.

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