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Affected Drug APV IDV RTV NFV SQV NFV IDV RTV NFV SQV LPVRTV APV IDV SQV LPVRTV Methadone Rifabutin Atorvastatin Simvastatin Pravastatin Sildena l MDMA (Ecstasy) GHB (hydroxy butyrate) Interacting Drug(s) Rifampin Phenytoin Carbamazepine Nevirapine Efavirenz Efavirenz Nevirapine Ritonavir Nel navir APV IDV NFV RTVSQV LPVRTV RTVSQV RTVSQV IDV SQV RTV RTV RTV RTVSQV Effect Protease inhibitor AUC decreased by 7092 Protease inhibitor concentrations potentially Forex trade Mitterfirmiansreut phenytoin and carbamazepine concentrations potentially increased or decreased Protease inhibitor AUC decreased by 2862 Methadone concentrations decreased Methadone concentrations possibly decreased Methadone concentrations possibly decreased Rifabutin AUC increased two to three- fold Atorvastatin AUC increased four to ve-fold Simvastatin AUC increased 32-fold Minimal change in pravastatin AUC Sildena l Forex trade Mitterfirmiansreut increased 2 to 11-fold Potential Increase in MDMA concentrations Potential increase in GHB concentrations Recommendations Avoid concomitant use Monitor anticonvulsant levels; consider measurement of protease inhibitor levels Use with ritonavir or increase dose Monitor for symptoms of opiate withdrawal and adjust dose if necessary Monitor for symptoms of opiate withdrawal and adjust dose if necessary Monitor for symptoms of opiate withdrawaland adjust dose if necessary Decrease dose to 150 mgday, exerted by binding and interference with transcription itself.

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